The Transcatheter Patch is a frameless and bioabsorbable device, used in the occlusion of heart defects. Device apposition is accomplished by balloon inflation, after which the patch begins to adhere to the cardiac tissues. Adequate adhesion takes approximately 48 hours, and is mediated by fibrin formation. The introducer and supporting balloon catheters keep the device immobilized, and are only removed after adequate adhesion has been achieved. Although the procedure has been shown to be safe in many patients, implanting catheters for an extended period of time is inconvenient compared to other percutaneous occlusion techniques. Our experimental work has studied techniques which accelerate the adhesion process. These techniques include the use of surgical adhesives and immediate patch release (catheter detaching mechanism).

ASD

Scholarly work describing the correction of Atrial Septal Defects using the Transcatheter Patch:

Transcatheter patch occlusion of secundum atrial septal defects: EB Sideris, S. Toumanides. B. Macuil, H. Leonard, M.Pursanov, A.Sokolov. SD Moulopoulos Am J Cardiol 2002; 89: 1082-1086

Transcatheter patch occlusion of experimental atrial septal defects. E.B. Sideris, C.E. Sideris, S.F. Stamatelopoulos, S.D. Moulopoulos. Cathet Cardiovasc Intervent 2002; 57:404-407

Transcatheter patch occlusion of secundum atrial septal defects: early clinical Experience. EB Sideris, S Toumanides, B. Cacuil, V. Varvarenko, B. Alekyan, S. Stamatelopoulos,  SD Moulopoulos, A. Sokolov.  Eur. Heart J. 2001:22 Suppl, P 538.

A disk device or the transcatheter patch for secundum ASD occlusion?  Sideris EB, Macuil B, Varvarenko V, Zamora R, Chandar J, Sandhu S, Palacios I, Lax D, Rao PS. Catheter. Cardiovasc. Interv. ; 2004; 62: 93:33

Experimental atrial septal defect occlusion using the transcatheter patch and Surgical adhesive. Sideris EB, Macuil B, Sideris VE, Moulopoulos SD. IACC supp. 2005 (Presented in 2005 , ACC meeting, Orlando ,Fl).

Transcatheter Patch Correction of non Secundum Atrial Septal Defects: Patient selection and clinical results. Sideris E.,Chamie F, Haddad G, Calachanis M, Toumanides S. Cardiol in the Young(Supplement 1) 2008;(18),97-157

Long term results of Transcatheter Patch Correction of Atrial Septal Defects: Benefits and problems of a frame-less bio-absorbable device. Sideris E, Macuil B, Prieto L, Zamora R, Calachanis M. Circulation suppl. 2008

VSD

Scholarly work describing the correction of Ventricular Septal Defects using the Transcatheter Patch:

Transcatheter patch occlusion of perimembranous ventricular septal defects. EB Sideris, B Macul, V. Varvarenko, S. Toumanides. Am J Cardiol 2005; in press

Transcatheter perimembranous ventricular septal defect occlusion by wireless devices. EB Sideris, B. Macuil, J. Zhang, C. Leonard. Eur. Heart J. 2001:22, suppl, 2536.

Transcatheter patch occlusion of perimembranous ventricular septal defects.  Sideris EB, Macuil M, Poursanov M, Toumanides S, Moulopoulos SD. JACC;2003 suppl 41:473A-157

Perimembranous ventricular septal defect occlusion in children, using the transcatheter patch. Sideris EB, Macuil B, Toumanides S, Poursanov M. Cardiol in the Young;2003 suppl. 13:23

Transcatheter patch occlusion of perimembranous ventricular septal defects, in surgical candidates. Sideris EB, Macuil B, Pursanov M, Toumnides S. JACC, suppl, March 2004

Transcatheter patch occlusion of perimembranous ventricular septal defects with surgical indications: Acute and medium-term results. Sedaris EB, Macuil B, Varvarenko V, Sokolov A, Toumanides S. JACC 2006;47 2910-66

LAA

Left atrial appentage obliteration in piglets. E.B. Sideris, S. Toumanides, M.Petrou, S.D. Moulopoulos. Cardiology in the Young, 2002

The optimal method for the obliteration of the atrial appendage in piglets: patch or device? Sideris EB, Toumanides S, Sideris C, Moulopoulos SD. Cathet. Cardiovasc. Interv. 2004; 62:100:11

Transcatheter patch obliteration of the left atrial appendage: Experimental validation and early clinical experience. Sideris EB, Toumanides S, Rokas S, Moulopoulos S. JACC 2006; 47 2901-63

PDA

The adult with the giant patent ductus arteriosus: The transcatheter occlusion challenge. EB. Sideris, PS Rao, B. Macuil, V.Varvarenko, R. Zamora, Circulation. 2001: 104 suppl, 593.

Accelerated transcatheter patch occlusion of large patent ductus arteriosus.  Sideris EB, Macuil B, Moguil R, Alekyan B. Cardiol in the Young;2003 suppl 13:35

Outpatient transcatheter patch occlusion of large patent ductus arteriosus and imembranous ventricular septal defect. Sideris EB, Macuil B, Varvarenko V, Alekyan B. Cathet. Cardiovasc. Interv.. 2004;  62:140:7

Other Studies

From Disk Devices to Transcatheter Patches: The Evolution of Wireless Heart Defect Occlusion.  E.B. Sideris, SE Sideris, S. Toumanides, SD Moulopoulos,    J. Interven. Cardiol. 2001; 14:211-214.

Transcatheter patch occlusion of  Heart Defects. E.B. Sideris, S.D. Moulopoulos. Cathet Cardiovasc Intervent 2004; 61:150-151

Transcatheter patch occlusion of heart defects. E.B. Sideris, S. Toumanides, B. Macuil, B. Alekyan, V. Varvarenko, S.D.  Moulopoulos. Cardiology in the Young, 2002 suppl

Left atrial appendage and patent foramen ovale transcatheter patch occlusion in Piglets: role of accelerated fibrin formation. Sideris EB, Pappa PG, Sideris CE, Moulopoulos SD. Cardiol in the Young; 2003 suppl.13:60

Accelerated transcatheter patch occlusion of heart defects: Experimental findings. Sideris EB, Toumanides S, Sideris C, Moulopoulos SD. Cathetet. Cardiov. Interv.; 2004 : 62:93:32

Effectiveness of transcatheter patch release with surgical adhesives in the occlusion of heart defects. Calachanis M, Macuil B, Zamora R, Coulson J, Toumanides S, Sideris E. Cardiol in the Young (Supplement 1)2007;(17),31-014-3

Other Investigations

At Custom Medical Devices we value innovation and consequently we conduct experimental research on a wide range of cardiovascular diseases and procedures. Presented below is a list of scholarly publications and case reports describing some of our work.

Fallot Tetralogy

New Advances in Transcatheter Cardiac Defect and Heart Valve Correction. Sideris E.B. J. Intervent. Cardiol. 12: 87-90, 1999

Transcatheter atrial septal defect occlusion in piglets by balloon detachable devices.  Sideris E.B, Kaneva A, Sideris C. Moulopoulos S., Cathet. Cardiovasc. Intervent, 51:529-534, 2000.

Total percutaneous correction of a Fallot Tetralogy variant with dominant pulmonic valve stenosis. Sideris EB, Macuil B, Justiniano S, Rao PS. Heart 2005; in press

Transcatheter placement of pulmonic and tricuspid valves in piglets. Sideris EB,  Sideris CE, Stamatelopoulos S, Toumanides S, Moulopoulos S. Circulation, 2002 supl II, 106: 620;3063

Is total Fallot tetralogy correction feasible? Early clinical experience and new experimental procedures. Sideris EB, Macuil B, Sideris C, Rao PS. Cathet.  Cardiovasc. Interv. 2004; 62: 138:01

Total Transcatheter Fallot Tetralogy Correction; early clinical experience and new experimental procedures. Sideris EB, Macuil B, Justiniano S, Sideris C. Cardiol in the Young; 2004 suppl

Transcatheter restriction of left ventricular cavity in piglets. Sideris EB, Toumanides S, Bramos D, Christianakis E, Sideris B, Moulopoulos SD. JACC (Supp B)2007:49(9):907-212,15B

Perventricular non surgical aortic valve placement with subsequent use of myocardial plugs. Sideris EB, Bramos D, Christianakis E, Sideris B, Moulopoulos SD. JACC(SupplementB):2007;49(9):907-213,15B

Perventricular non surgical aortic reconstruction. Sideris E, Bramos D, Sideris B, Calahanis M, Christianakis E, Moulopoulos S. Cardiol in the Young(Supplement 1) 2007;(17),21-09-4